Biodegradable‐Polymer‐Blend‐Based Surgical Sealant with Body‐Temperature‐Mediated Adhesion. (10th November 2015)

• Record Type: Journal Article
• Authors: Behrens, Adam M.; Lee, Nora G.; Casey, Brendan J.; Srinivasan, Priya; Sikorski, Michael J.; Daristotle, John L.; Sandler, Anthony D.; Kofinas, Peter
• Is Part Of: Advanced materials. Volume 27:Number 48(2015)
• Page Start: 8056
• Page End: 8061
• Publication Date: 2015-11-10
• Subjects: biodegradable polymers -- solution blow spinning -- surgical sealants -- temperature responsive; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201503691
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer–substrate interfacial interactions leading to improved adhesion and surgical sealant performance.