A lncRNA to repair DNA. (29th September 2015)

• Record Type: Journal Article
• Authors: Lukas, Jiri; Altmeyer, Matthias
• Is Part Of: EMBO reports. Volume 16:Number 11(2015:Nov.)
• Page Start: 1413
• Page End: 1414
• Publication Date: 2015-09-29
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.15252/embr.201541309
• Languages: English
• ISSNs: 1469-221X

Abstract

Abstract : Long non‐coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al 1 identify the DNA damage‐induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al 1 thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage. Abstract : In this issue of EMBO Reports, Misteli and colleagues show that the lncRNA DDSR1 promotes DNA repair by homologous recombination by sequestering BRCA1 and hnRNPUL1.