Bottom‐Up Instructive Quality Control in the Biofabrication of Smart Protein Materials. (28th October 2015)

• Record Type: Journal Article
• Authors: Rueda, Fabián; Céspedes, María Virtudes; Conchillo‐Solé, Oscar; Sánchez‐Chardi, Alejandro; Seras‐Franzoso, Joaquin; Cubarsi, Rafael; Gallardo, Alberto; Pesarrodona, Mireia; Ferrer‐Miralles, Neus; Daura, Xavier; Vázquez, Esther; García‐Fruitós, Elena; Mangues, Ramón; Unzueta, Ugutz; Villaverde, Antonio
• Is Part Of: Advanced materials. Volume 27:Number 47(2015)
• Page Start: 7816
• Page End: 7822
• Publication Date: 2015-10-28
• Subjects: biodistribution -- biofabrication -- nanoparticles -- protein materials -- cell quality control; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201503676
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self‐assembling, cell‐targeted protein nanoparticles, including biodistribution upon in vivo administration.