Cutaneous drug toxicity from 2, 4‐dinitrophenol (DNP): Case report and histological description. (4th November 2014)

• Record Type: Journal Article
• Authors: Le, Patricia; Wood, Benjamin; Kumarasinghe, Sujith Prasad
• Is Part Of: Australasian journal of dermatology. Volume 56:Number 4(2015:Nov.)
• Page Start: 307
• Page End: 309
• Publication Date: 2014-11-04
• Subjects: 2 -- 4‐dinitrophenol -- bodybuilding -- dinitrophenol -- DNP -- toxicity -- weight loss; Dermatology -- Periodicals; Dermatology -- Australasia -- Periodicals; 616.5005
• DOI: 10.1111/ajd.12237
• Languages: English
• ISSNs: 0004-8380

Abstract

Abstract: The use of 2, 4‐dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2, 4‐DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2, 4‐DNP has not been reported since the 1930s. We report a case of a 21‐year‐old bodybuilding enthusiast who presented with a toxic exanthem after taking 2, 4‐DNP, and describe the first skin biopsy findings in a case of 2, 4‐DNP toxicity.