Excipients in Oral Antihistamines Can Perpetuate Allergic Contact Dermatitis. Issue 6 (4th September 2015)

• Record Type: Journal Article
• Authors: Tocci, Elizabeth M.; Robinson, Amanda; Belazarian, Leah; Foley, Elizabeth; Wiss, Karen; Silvestri, Dianne L.
• Is Part Of: Pediatric dermatology. Volume 32:Issue 6(2015)
• Page Start: e242
• Page End: e244
• Publication Date: 2015-09-04
• Subjects: Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.12668
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: Propylene glycol is a well‐documented causative agent of allergic contact dermatitis (ACD). It is also reported to cause systemic dermatitis after ingestion of foods or medicines containing it and after intravenous injection of a medicine with propylene glycol in its base. We describe two adolescents with sensitivity to propylene glycol confirmed by patch testing whose dermatitis improved dramatically after cessation of oral antihistamines containing propylene glycol. We report these cases to alert providers to the potential for worsening of ACD due to systemic exposure to propylene glycol in patients with a cutaneous sensitivity to the allergen.