Blood–brain barrier and brain fatty acid uptake: Role of arachidonic acid and PGE2. (17th September 2015)

• Record Type: Journal Article
• Authors: Murphy, Eric J.
• Is Part Of: Journal of neurochemistry. Volume 135:Number 5(2015:Dec.)
• Page Start: 845
• Page End: 848
• Publication Date: 2015-09-17
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.13289
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract: How do fatty acids enter the brain and what role, if any, do membrane and cytosolic fatty acid binding proteins have on facilitating this process? This is a fundamental question that many lipid neurochemists will freely admit they cannot answer in any kind of definitive manner. A study by Dalvi and colleagues in this issue of the Journal of Neurochemistry now adds to our knowledge in this field. Among other important observations, their experiments demonstrate that a physiological level of arachidonic acid (ARA), that could be associated with many different physiological and pathophysiological states, increases permeability in a model of the human blood brain barrier (BBB) in the absence of cytokines. This last point is very important as it suggests increases in BBB permeability may occur in situations other than those associated with increases in tumor necrosis factor a (TNF α ) and interleukin1b (IL1 β ), giving additional options for developing drugs impacting BBB permeability. Abstract : How do fatty acids enter the brain and what role, if any, do membrane and cytosolic fatty acid binding proteins have on facilitating this process? This is a fundamental question that many lipid neurochemists will freely admit they cannot answer in any kind of definitive manner. A study by Dalvi and colleagues in this issue of the Journal of Neurochemistry now adds to our knowledge in this field. Among other important observations, their experiments demonstrate that a physiological level of arachidonic acid (ARA), that could be associated with many different physiological and pathophysiological states, increases permeability in a model of the human blood brain barrier (BBB) in the absence of cytokines. This last point is very important as it suggests increases in BBB permeability may occur in situations other than those associated with increases in tumor necrosis factor a (TNF α ) and interleukin1b (IL1 β ), giving additional options for developing drugs impacting BBB permeability. Read the full article ' Exogenous arachidonic acid mediates permeability of human brain microvessel endothelial cells through prostaglandin E 2 activation of EP 3 and EP 4 receptors ' on page867