Osteonecrosis of the jaw in a patient receiving cabozantinib. (December 2015)

• Record Type: Journal Article
• Authors: Marino, R; Orlandi, F; Arecco, F; Gandolfo, S; Pentenero, M
• Is Part Of: Australian dental journal. Volume 60:Number 4(2015:Dec.)
• Page Start: 528
• Page End: 531
• Publication Date: 2015-12
• Subjects: Antiangiogenic drugs -- cabozantinib -- medullary thyroid cancer -- osteonecrosis of the jaw -- VEGF inhibition; Dentistry -- Periodicals; Dentistry -- Periodicals; Dentisterie -- Australie -- Périodiques; Tandheelkunde; 617.6
• DOI: 10.1111/adj.12254
• Languages: English
• ISSNs: 0045-0421

Abstract

Abstract: Since the discovery of bisphosphonate‐related osteonecrosis of the jaw, there has been increasing evidence in recent years of osteonecrosis induced by drugs other than bisphosphonates, mainly agents with antiangiogenic and antiosteoclastic activity. Mandibular osteonecrosis was observed in a 51‐year‐old female with medullary thyroid cancer receiving cabozantinib, a new tyrosine kinase inhibitor having antiangiogenic activity. The bone necrosis appeared after a dental extraction. The clinical, radiographic and histologic picture of a chronic non‐healing extraction socket was consistent with drug‐induced osteonecrosis of the jaw. Healing was achieved by segmental ostectomy. The osteonecrosis was likely associated with a vascular endothelial growth factor (VEGF) pathway inhibition, implying inhibition of angiogenesis and hampering of the local host defence mechanisms.