Cryptococcal meningitis due to Cryptococcus neoformans genotype AFLP1/VNI in Iran: a review of the literature. Issue 12 (7th October 2015)

• Record Type: Journal Article
• Authors: Badali, Hamid; Alian, Shahriar; Fakhim, Hamed; Falahatinejad, Mahsa; Moradi, Ali; Mohammad Davoudi, Mehrnaz; Hagen, Ferry; Meis, Jacques F.
• Is Part Of: Mycoses. Volume 58:Issue 12(2015)
• Page Start: 689
• Page End: 693
• Publication Date: 2015-10-07
• Subjects: Cryptococcus species -- HIV -- molecular identification -- Iran; Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12415
• Languages: English
• ISSNs: 0933-7407

Abstract

Summary: Cryptococcal meningitis is the most important opportunistic fungal infection with a high mortality in HIV‐patients in less developed regions. Here, we report a case of cryptococcal meningitis in a 49‐year‐old HIV‐positive female due to Cryptococcus neoformans (serotype A, mating‐type alpha, genotype AFLP1/VNI) in Sari, Iran. In vitro antifungal susceptibility tests showed MICs of isavuconazole (0.016 μg ml −1 ), voriconazole (0.031 μg ml −1 ), posaconazole (0.031 μg ml −1 ), itraconazole (0.063 μg ml −1 ), amphotericin B (0.125 μg ml −1 ) and fluconazole (8 μg ml −1 ). Despite immediate antifungal therapy, the patient died 4 days later due to respiratory failure. Cryptococcal infections have been infrequently reported from Iran and therefore we analysed all published cases of cryptococcosis in Iran since the first reported case from 1969.