Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum. (30th October 2015)

• Record Type: Journal Article
• Authors: Cuesta‐Rubio, Osmany; Oubada, Ahmad; Bello, Adonis; Maes, Louis; Cos, Paul; Monzote, Lianet
• Is Part Of: Phytotherapy research. Volume 29:Number 12(2015:Dec.)
• Page Start: 1991
• Page End: 1994
• Publication Date: 2015-10-30
• Subjects: Calophyllum antillanum -- Calophyllum inophyllum -- antimicrobial -- Plasmodium falciparum; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.5506
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : The Calophyllum genus is well‐known for its antimicrobial and cytotoxic activities, and therefore, we analyzed these biological activities for resins of Calophyllum antillanum and Calophyllum inophyllum growing in Cuba. C . antillanum resins showed a potent activity against Plasmodium falciparum (IC50 = 0.3 ± 0.1 µg/mL), while its cytotoxicity against MRC‐5 cells was much lower (IC50 = 21.6 ± 1.1 µg/mL). In contrary, the resin of C . inophyllum showed an unspecific activity. The presence of apetalic acid, isoapetalic acid, calolongic acid, pinetoric acid I, pinetoric acid II, isocalolongic acid, pinetoric acid III, and isopinetoric acid III in C . antillanum resins was also confirmed. These results demonstrated for the first time the potential activity of C . antillanum resins against P . falciparum . Copyright © 2015 John Wiley & Sons, Ltd.