Assessment of Oxidative Stress in Patients with an Isolated Traumatic Brain Injury Using Disposable Electrochemical Test Strips. Issue 11 (15th July 2015)

• Record Type: Journal Article
• Authors: Rael, Leonard T.; Bar‐Or, Raphael; Kelly, Michael T.; Carrick, Matthew M.; Bar‐Or, David
• Is Part Of: Electroanalysis. Volume 27:Issue 11(2015:Nov.)
• Page Start: 2567
• Page End: 2573
• Publication Date: 2015-07-15
• Subjects: Isolated traumatic brain injury -- Oxidative stress -- Human plasma -- Redox chemistry -- Sensors; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201500178
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: The barriers to using plasma redox potential as a measure of oxidative stress in patients are the use of specialized equipment, necessity of sterilization between tests, and inconsistent electrode surfaces and cell geometry. These problems are resolved using disposable test strips with built in electrochemical cells. Measuring the electrode potential at a small current yields a stable value that is ∼50 mV higher for isolated traumatic brain injury (ITBI) patients than for healthy individuals. Even with natural variations within blood chemistry, this simple method may be clinically useful for assessing the degree of oxidative stress and injury severity in ITBI patients. Abstract :