ChemInform Abstract: Organocatalytic Cascade Reaction for the Asymmetric Synthesis of Novel Chroman‐Fused Spirooxindoles That Potently Inhibit Cancer Cell Proliferation. Issue 50 (December 2015)

• Record Type: Journal Article
• Authors: Zhou, Rui; Wu, Qinjie; Guo, Mingrui; Huang, Wei; He, Xianghong; Yang, Lei; Peng, Fu; He, Gu; Han, Bo
• Is Part Of: ChemInform. Volume 46:Issue 50(2015)
• Page Start: no
• Page End: no
• Publication Date: 2015-12
• Subjects: spirocyclic compounds (heterocyclic compounds) -- benzopyran derivatives -- indole derivatives, isoindole derivatives -- diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) -- cascade reactions, domino reactions, tandem reactions -- anticarcinogenic activity, anticancer activity -- organocatalysis; Chemistry -- Abstracts -- Periodicals; 540.5
• DOI: 10.1002/chin.201550108
• Languages: English
• ISSNs: 0931-7597

Abstract

Abstract: The tandem oxa—Michael—Michael reaction of 2‐nitrovinyl phenols (I) with enal (II) followed by reaction of intermediate chromanes with oxindoles (III) leads to chroman‐fused spirooxindoles (IV) with high enantioselectivities and good diastereoselectivities.