Using Small Molecules to Dissect Non‐apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis. Issue 18 (16th October 2015)

• Record Type: Journal Article
• Authors: Dong, Ting; Liao, Daohong; Liu, Xiaohui; Lei, Xiaoguang
• Is Part Of: Chembiochem. Volume 16:Issue 18(2015)
• Page Start: 2557
• Page End: 2561
• Publication Date: 2015-10-16
• Subjects: cancer -- ferroptosis -- necroptosis -- programmed cell death -- pyroptosis -- signal transduction; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201500422
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract: Genetically programmed cell death is a universal and fundamental cellular process in multicellular organisms. Apoptosis and necroptosis, two common forms of programmed cell death, play vital roles in maintenance of homeostasis in metazoans. Dysfunction of the regulatory machinery of these processes can lead to carcinogenesis or autoimmune diseases. Inappropriate death of essential cells can lead to organ dysfunction or even death; ischemia–reperfusion injury and neurodegenerative disorders are examples of this. Recently, novel forms of non‐apoptotic programmed cell death have been identified. Although these forms of cell death play significant roles in both physiological and pathological conditions, the detailed molecular mechanisms underlying them are still poorly understood. Here, we discuss progress in using small molecules to dissect three forms of non‐apoptotic programmed cell death: necroptosis, ferroptosis, and pyroptosis. Abstract : Genetically programmed cell death is a universal and fundamental cellular process, and dysfunction can lead to many human diseases. We highlight recent progress in dissecting non‐apoptotic programmed cell death, such as necroptosis, ferroptosis, and pyroptosis. A number of new molecular mechanisms for the signal transduction of cell death have been elucidated.