A Multifunctional Subphthalocyanine Nanosphere for Targeting, Labeling, and Killing of Antibiotic‐Resistant Bacteria. Issue 50 (23rd October 2015)

• Record Type: Journal Article
• Authors: Roy, Indranil; Shetty, Dinesh; Hota, Raghunandan; Baek, Kangkyun; Kim, Jeesu; Kim, Chulhong; Kappert, Sandro; Kim, Kimoon
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 50(2015)
• Page Start: 15152
• Page End: 15155
• Publication Date: 2015-10-23
• Subjects: antibiotic resistance -- nanostructures -- photodynamic therapy -- self‐assembly -- subphthalocyanines; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201507140
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Developing a material that can combat antibiotic‐resistant bacteria, a major global health threat, is an urgent requirement. To tackle this challenge, we synthesized a multifunctional subphthalocyanine (SubPc) polymer nanosphere that has the ability to target, label, and photoinactivate antibiotic‐resistant bacteria in a single treatment with more than 99 % efficiency, even with a dose as low as 4.2 J cm −2 and a loading concentration of 10 nM . The positively charged nanosphere shell composed of covalently linked SubPc units can increase the local concentration of photosensitizers at therapeutic sites. The nanosphere shows superior performance compared to corresponding monomers presumably because of their enhanced water dispersibility, higher efficiency of singlet‐oxygen generation, and phototoxicity. In addition, this material is useful in fluorescence labeling of living cells and shows promise in photoacoustic imaging of bacteria in vivo. Abstract : Killing me softly : A multifunctional, water‐dispersible nanosphere composed of covalently linked subphthalocyanine units was synthesized. The nanosphere can target, label, and photoinactivate antibiotic‐resistant bacteria with exceptional efficiency even at a low dosage. The nanomaterial also shows promise in photoacoustic imaging of bacteria in vivo.