Cover Picture: Regiochemistry‐Directed Syntheses of Polyhydroxylated Alkaloids from Chiral Aziridines (Asian J. Org. Chem. 12/2015). Issue 12 (16th November 2015)

• Record Type: Journal Article
• Authors: Eum, Heesung; Choi, Jihye; Cho, Cheon‐Gyu; Ha, Hyun‐Joon
• Is Part Of: Asian journal of organic chemistry. Volume 4:Issue 12(2015:Dec.)
• Page Start: 1325
• Page End: 1325
• Publication Date: 2015-11-16
• Subjects: alkaloids -- asymmetric synthesis -- aziridines -- polyhydroxylated compounds -- regiochemistry; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201500380
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract : The syntheses of two different classes of compounds branched from a common synthetic intermediate were developed by Hyun‐Joon Ha and co‐workers. Two different regiochemical pathways of aziridine ring‐opening of 2‐(dihydroxylated‐alkyl)aziridines provide easy access to two diverse classes of compounds including a variety of pyrrolidine‐ and piperidine‐based polyhydroxylated natural products and their analogues. This strategy, so called "regiochemistry‐directed branches for 2‐substituted aziridines", is applicable for the easy preparation of structurally diverse and biologically important molecules. More information can be found in the full paper by H.‐J. Ha et al. (DOI:10.1002/ajoc.201500285 ).