Anticancer Platelet‐Mimicking Nanovehicles. (29th September 2015)

• Record Type: Journal Article
• Authors: Hu, Quanyin; Sun, Wujin; Qian, Chengen; Wang, Chao; Bomba, Hunter N.; Gu, Zhen
• Is Part Of: Advanced materials. Volume 27:Number 44(2015)
• Page Start: 7043
• Page End: 7050
• Publication Date: 2015-09-29
• Subjects: biomimetic -- drug delivery -- nanomedicine -- nanoparticle -- platelet; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201503323
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A core–shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site‐specific delivery of an extracellularly active drug and an intracellular functional small‐molecular drug, leading to enhanced antitumor efficacy. This PM‐coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.