2′‐Methoxyacetophenone: An Efficient Photosensitizer for Cyclobutane Pyrimidine Dimer Formation. Issue 16 (17th September 2015)

• Record Type: Journal Article
• Authors: Liu, Lizhe; Pilles, Bert M.; Reiner, Anne M.; Gontcharov, Julia; Zinth, Wolfgang
• Is Part Of: Chemphyschem. Volume 16:Issue 16(2015)
• Page Start: 3483
• Page End: 3487
• Publication Date: 2015-09-17
• Subjects: DNA photolesion -- photochemistry -- photosensitizer -- thymine -- time-resolved spectroscopy; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201500582
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: Stationary and time‐resolved experiments show that 2′‐methoxyacetophenone (2‐M) is an interesting compound for the investigation of triplet states in thymine samples. Time‐resolved emission experiments show that the fluorescence lifetime of 2‐M is 660 ps. A similar time constant of 680 ps is found in transient IR experiments. The data indicate efficient intersystem crossing (≈97 %) from the fluorescent singlet state to the triplet state. The lifetime of the triplet state of 2‐M dissolved in D2 O at room temperature and ambient oxygen concentration is 400 ns. 2‐M has a strong absorption in the UV‐A range and can photosensitize the triplet state of a thymidine dinucleotide with light at a wavelength of 320 nm. The experiments show that 2‐M is well‐suited for time‐resolved experiments on the triplet‐sensitizing process. Abstract : A triplet threat : 2′‐Methoxyacetophenone (2‐M) was characterized as an efficient photosensitizer for the triplet state of thymine dinucleotides, which is on the way to the cyclobutane pyrimidine dimer photolesion. Time‐resolved IR experiments were performed to quantify the photophysical properties of 2‐M (see picture).