Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome‐Localized Photosensitizers for Two‐Photon Photodynamic Therapy. Issue 47 (8th October 2015)

• Record Type: Journal Article
• Authors: Huang, Huaiyi; Yu, Bole; Zhang, Pingyu; Huang, Juanjuan; Chen, Yu; Gasser, Gilles; Ji, Liangnian; Chao, Hui
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 47(2015)
• Page Start: 14049
• Page End: 14052
• Publication Date: 2015-10-08
• Subjects: cancer therapy -- lysosomes -- photodynamic therapy -- ruthenium -- singlet oxygen; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201507800
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Photodynamic therapy (PDT) is a noninvasive medical technique that has received increasing attention over the last years and been applied for the treatment of certain types of cancer. However, the currently clinically used PDT agents have several limitations, such as low water solubility, poor photostability, and limited selectivity towards cancer cells, aside from having very low two‐photon cross‐sections around 800 nm, which limits their potential use in TP‐PDT. To tackle these drawbacks, three highly positively charged ruthenium(II) polypyridyl complexes were synthesized. These complexes selectively localize in the lysosomes, an ideal localization for PDT purposes. One of these complexes showed an impressive phototoxicity index upon irradiation at 800 nm in 3D HeLa multicellular tumor spheroids and thus holds great promise for applications in two‐photon photodynamic therapy. Abstract : Very positive : The title complexes can be used for two‐photon photodynamic therapy (PDT). They selectively accumulate in lysosomes through endocytosis and exhibit high phototoxicity against 2D monolayer cancer cells and 3D multicellular tumor spheroids upon two‐photon laser irradiation.