X‐ray Radiation‐Controlled NO‐Release for On‐Demand Depth‐Independent Hypoxic Radiosensitization. Issue 47 (23rd July 2015)

• Record Type: Journal Article
• Authors: Fan, Wenpei; Bu, Wenbo; Zhang, Zhen; Shen, Bo; Zhang, Hui; He, Qianjun; Ni, Dalong; Cui, Zhaowen; Zhao, Kuaile; Bu, Jiwen; Du, Jiulin; Liu, Jianan; Shi, Jianlin
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 47(2015)
• Page Start: 14026
• Page End: 14030
• Publication Date: 2015-07-23
• Subjects: hypoxic radiosensitization -- luminescent imaging -- NO release -- on‐demand therapy -- X‐ray radiation; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201504536
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Multifunctional stimuli‐responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on‐demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X‐ray‐controlled NO‐releasing upconversion nanotheranostic system (termed as PEG‐USMSs‐SNO) by engineering UCNPs with S‐nitrosothiol (R‐SNO)‐grafted mesoporous silica. The PEG‐USMSs‐SNO is designed to respond sensitively to X‐ray radiation for breaking down the SN bond of SNO to release NO, which leads to X‐ray dose‐controlled NO release for on‐demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live‐body permeability of X‐ray, our developed PEG‐USMSs‐SNO may provide a new technique for achieving depth‐independent controlled NO release and positioned radiotherapy enhancement against deep‐seated solid tumors. Abstract : A novel nanotheranostic system based on X‐ray radiation‐controlled NO‐release enables simultaneous luminescent imaging and controllable NO‐sensitized radiation enhancement effects without depth dependence. The results will lead to the on‐demand therapy of deep‐seated solid tumors with very few adverse effects by simply manipulating the appropriate X‐ray dose.