Catalytic Asymmetric Transfer Hydrogenation of Imines: Recent Advances. Issue 5 (25th August 2015)

• Record Type: Journal Article
• Authors: Foubelo, Francisco; Yus, Miguel
• Is Part Of: Chemical record. Volume 15:Issue 5(2015:Oct.)
• Page Start: 907
• Page End: 924
• Publication Date: 2015-08-25
• Subjects: asymmetric synthesis -- homogeneous catalysis -- hydrogen transfer, imines -- organocatalysis; Chemistry -- Periodicals; 540
• DOI: 10.1002/tcr.201500203
• Languages: English
• ISSNs: 1527-8999

Abstract

Abstract: In this review article recent developments in the asymmetric transfer hydrogenation of imines from 2008 up to today are presented. The main methodology involves either metal‐catalyzed procedures in the presence of a chiral ligand or organocatalyzed technologies using a Hantzsch ester and a chiral BINOL‐derived phosphoric acid. The most important procedures are collected, paying special attention to the application of this methodology in synthetic organic chemistry. Abstract : The asymmetric transfer hydrogenation of imines has been demonstrated to be a useful technique to access chiral amines with high optical purity. The processes proceeded effectively under organometallic catalysis in the presence of a chiral ligand and using isopropanol or formic acid as the hydrogen source. More recently, organocatalysis using a Hantzsch ester and a chiral phosphoric acid derived from BINOL has emerged as an environmentally friendly alternative procedure for the ATH of imines.