Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin‐Induced Gastric Ulcer. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Atalay, Fadime; Odabasoglu, Fehmi; Halici, Mesut; Cakir, Ahmet; Cadirci, Elif; Aslan, Ali; Aydin Berktas, Ozlem; Kazaz, Cavit
• Is Part Of: Chemistry & biodiversity. Volume 12:Issue 11(2015:Nov.)
• Page Start: 1756
• Page End: 1767
• Publication Date: 2015-11
• Subjects: Lobaria pulmonaria -- Rhizonyl alcohol -- Rhizonaldehyde -- Gastroprotective effect -- Antioxidants; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201400432
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Two lichen metabolites, rhizonaldehyde (1 ) and rhizonyl alcohol (2 ), were isolated from the acetone extract of Lobaria pulmonaria by chromatographic methods, and their chemical structures were determined by UV/VIS, IR, and 1D‐ and 2D‐NMR spectroscopic methods. The gastroprotective and in vivo antioxidant activities of extracts of L. pulmonaria and its metabolites, 1 and2, were investigated in indomethacin‐induced ulcer models in rats. The gastric lesions were significantly reduced by acetone, hexane, and CHCl3 extracts, with 75.3–41.5% inhibition. Rhizonyl alcohol (2 ) significantly reduced the gastric lesions with an inhibition rate of 84.6–42.8%, whereas rhizonaldehyde (1 ) significantly increased the gastric lesions. Antioxidant parameters and myeloperoxidase activities were also evaluated in the gastric tissues of the rats. Indomethacin caused oxidative stress, which resulted in lipid peroxidation in gastric tissues by decreasing the levels of the antioxidants as compared to healthy rat tissues. In contrast to indomethacin, all extracts and rhizonyl alcohol (2 ) caused a significant decrease in lipid peroxidation levels and an increase in antioxidant parameters, superoxide dismutase, glutathione peroxidase, and glutathione‐ S ‐transferase, and reduced glutathione in gastric tissues. The administration of rhizonyl alcohol (2 ) also resulted in a decrease in gastric myeloperoxidase activity increased by indomethacin. The gastroprotective effect of rhizonyl alcohol (2 ) can be attributed to its antioxidant properties and its suppressing effect on neutrophil infiltration into gastric tissues. Abstract :