Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother. Issue 1 (16th July 2015)

• Record Type: Journal Article
• Authors: Zavattoni, Maurizio; Rustico, Mariangela; Tassis, Beatrice; Lombardi, Giuseppina; Furione, Milena; Piralla, Antonio; Baldanti, Fausto
• Is Part Of: Journal of medical virology. Volume 88:Issue 1(2016)
• Page Start: 120
• Page End: 126
• Publication Date: 2015-07-16
• Subjects: congenital disease -- maternal infection -- amniocentesis -- human cytomegalovirus; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.24313
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses. J. Med. Virol. 88:120–126, 2016 . © 2015 Wiley Periodicals, Inc.