Destruction and Construction: Application of Dearomatization Strategy in Aromatic Carbon–Nitrogen Bond Functionalization. (9th November 2015)

• Record Type: Journal Article
• Authors: Wang, Shuo‐En; Wang, Linfei; He, Qiuqin; Fan, Renhua
• Is Part Of: Angewandte Chemie. Volume 127:Number 46(2015)
• Page Start: 13859
• Page End: 13862
• Publication Date: 2015-11-09
• Subjects: C‐N‐Funktionalisierung -- Cyanide -- Desaromatisierung -- Quartäre Kohlenstoffzentren -- Synthesemethoden; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201508161
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The formation of carbon–carbon bonds through the functionalization of aromatic carbon–nitrogen bonds is a highly attractive synthetic strategy in the synthesis of aromatic molecules. In this paper, we report a novel aromatic carbon–nitrogen bond functionalization reaction by using a simple dearomatization strategy. Through this process para ‐substituted anilines serve as a potential aryl source in the construction of a range of functionalized aromatic molecules, such as quaternary carbon centers, α‐keto esters, and aldehydes.