The effects of camicinal, a novel motilin agonist, on gastro‐esophageal function in healthy humans—a randomized placebo controlled trial. Issue 11 (8th September 2015)

• Record Type: Journal Article
• Authors: Hobson, R.; Farmer, A. D.; Dewit, O. E.; O'Donnell, M.; Hacquoil, K.; Robertson, D.; Barton, M. E.; Dukes, G. E.
• Is Part Of: Neurogastroenterology & motility. Volume 27:Issue 11(2015:Nov.)
• Page Start: 1629
• Page End: 1637
• Publication Date: 2015-09-08
• Subjects: Gastrointestinal system -- Motility -- Periodicals; Gastrointestinal system -- Innervation -- Periodicals; 616.33
• DOI: 10.1111/nmo.12663
• Languages: English
• ISSNs: 1350-1925

Abstract

<abstract abstract-type="main" id="nmo12663-abs-0001"> <title>Abstract</title> <sec id="nmo12663-sec-0001" sec-type="section"> <title>Background</title> <p>A proportion of patients with foregut dysmotility fail to respond to standard interventions. Motilin agonists may be beneficial in this group. We aimed to determine the effect of camicinal, a novel motilin agonist, on gastrointestinal physiology in healthy volunteers.</p> </sec> <sec id="nmo12663-sec-0002" sec-type="section"> <title>Methods</title> <p>Healthy male subjects were randomly assigned to receive a single dose of 125 mg camicinal or placebo in a double‐blind cross‐over design. Esophageal function and reflux indices were assessed using high‐resolution manometry (pre and 1.5‐h post dose) and 24‐h ambulatory multichannel intraluminal impedance/pH. After a standardized meal, subjects ingested a wireless motility capsule from which compartmental transit times and motility indices were derived. Subjects were restudied with the alternate intervention after 7 days.</p> </sec> <sec id="nmo12663-sec-0003" sec-type="section"> <title>Key Results</title> <p>The study subjects (12 male, mean age 47.4 years, range 22–55) tolerated the drug well, except one who exhibited mild abdominal pain on both placebo and camicinal. In comparison to placebo, gastric emptying time (GET) was accelerated following camicinal (−115.4 min, 95% confidence interval −194.4, −36.4, <italic>p</italic> = 0.009). No effect was demonstrable on esophageal function, small bowel, colonic, or whole bowel transit times and motility indices. With camicinal, as part of a <italic>post hoc</italic> analysis, there was a trend association between the percentage reduction in GET and total number of acidic reflux events (<italic>r</italic> = 0.56, <italic>p</italic> = 0.09).</p> </sec> <sec id="nmo12663-sec-0004" sec-type="section"> <title>Conclusions & Inferences</title> <p>Camicinal decreases GET and was generally well‐tolerated. In health, the direct effects of camicinal are on accelerating GET with a potential secondary benefit of reducing reflux events, which warrant further exploration in patient cohorts.</p> </sec> </abstract>