Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer. Issue 6 (22nd September 2015)

• Record Type: Journal Article
• Authors: Matsuo, Koji; Garcia‐Sayre, Jocelyn; Medeiros, Fabiola; Casabar, Jennifer K.; Machida, Hiroko; Moeini, Aida; Roman, Lynda D.
• Is Part Of: Journal of surgical oncology. Volume 112:Issue 6(2015:Nov. 01)
• Page Start: 669
• Page End: 676
• Publication Date: 2015-09-22
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.24049
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso24049-sec-0001" sec-type="section"> <title>Background and Objectives</title> <p>To determine the significance of depth and extent of lymphovascular space invasion (LVSI) on lymph node metastasis and recurrence in endometrial cancer.</p> </sec> <sec id="jso24049-sec-0002" sec-type="section"> <title>Methods</title> <p>A case‐control study was conducted to examine LVSI‐positive (n = 70) and LVSI‐negative (n = 641) stage I–III endometrial cancer cases that underwent hysterectomy‐based surgical staging. The risk of lymph node metastasis and distant recurrence was estimated based on LVSI patterns.</p> </sec> <sec id="jso24049-sec-0003" sec-type="section"> <title>Results</title> <p>In multivariate analysis, deep (>50% invasion), and extensive (≥7 foci/slide) LVSI patterns had a significantly increased risk of lymph node metastasis (incidence 57.6% and 72.7%, odds ratio 33.8 and 49.9, respectively, <italic>P </italic>< 0.001) as compared to other traditional uterine factors (>50% myometrial tumor invasion, cervical stromal invasion, and adnexal involvement: incidence range 30.4–37.9%, odds ratio range 3.80–7.03). Deep and extensive of LVSI patterns were both significantly correlated to distant recurrence (<italic>P </italic>< 0.001). Among women who received postoperative chemotherapy, deep and extensive LVSI patterns did not have increased risks for distant recurrence compared to no LVSI (<italic>P</italic> = 0.47 and 0.32, respectively). Among women who received postoperative radiotherapy, the depth of LVSI was significantly associated with recurrence outside the radiated field (<italic>P</italic> = 0.02).</p> </sec> <sec id="jso24049-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Depth and extent of LVSI are important predictors for lymph node metastasis and distant recurrence in endometrial cancer. <italic>J. Surg. Oncol. 2015;112:669–676</italic>. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>