Lack of predictive power of plasma lipids or lipoproteins for gestational diabetes mellitus in Japanese women. Issue 6 (20th May 2015)

• Record Type: Journal Article
• Authors: Iimura, Yuko; Matsuura, Masaaki; Yao, Zemin; Ito, Satoru; Fujiwara, Mutsunori; Yoshitsugu, Michiyasu; Miyauchi, Akito; Hiyoshi, Toru
• Is Part Of: Journal of diabetes investigation. Volume 6:Issue 6(2015:Dec.)
• Page Start: 640
• Page End: 646
• Publication Date: 2015-05-20
• Subjects: Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.12363
• Languages: English
• ISSNs: 2040-1116

Abstract

<abstract abstract-type="main" id="jdi12363-abs-0001"> <title>Abstract</title> <sec id="jdi12363-sec-0001" sec-type="section"> <title>Aims/Introduction</title> <p>To determine the diagnostic potential of plasma lipids and apolipoproteins in gestational diabetes mellitus (GDM), we carried out a retrospective cohort study of 1, 161 Japanese women at 20–28 weeks of gestation who underwent a glucose challenge test (GCT).</p> </sec> <sec id="jdi12363-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>A total of 1, 161 Japanese women at 20–28 weeks of gestation underwent a GCT. Participants with a positive test (GCT[+]) underwent a subsequent oral glucose tolerance test. Clinical and biochemical parameters were determined and quantification of apolipoproteins (Apo), including ApoB, ApoB48, ApoA‐I and ApoC‐III, was carried out.</p> </sec> <sec id="jdi12363-sec-0003" sec-type="section"> <title>Results</title> <p>The prevalence of GCT(+; with a 130 mg/dL glucose cut‐off) and GDM was 20% and 4%, respectively. There was a trend for increased triglycerides and ApoC‐III in GDM(+) participants. However, the difference in plasma triglycerides, ApoC‐III or ApoB48 did not reach statistical significance between GDM(+) and GDM(−) women. Values of 1‐h glucose (<italic>P </italic>< 0.001) and fasting glucose (<italic>P </italic>= 0.002) were significant risk factors for GDM.</p> </sec> <sec id="jdi12363-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Prediction of GDM using only the ApoC‐III value is not easy, although triglycerides and ApoC‐III were higher in the GDM(+) group. The present findings show no significant difference in plasma lipid levels between women diagnosed with GDM and those with normal glucose tolerance.</p> </sec> </abstract>