Chemically Locked Bicelles with High Thermal and Kinetic Stability. (16th September 2015)

• Record Type: Journal Article
• Authors: Matsui, Ryoichi; Ohtani, Masataka; Yamada, Kuniyo; Hikima, Takaaki; Takata, Masaki; Nakamura, Takashi; Koshino, Hiroyuki; Ishida, Yasuhiro; Aida, Takuzo
• Is Part Of: Angewandte Chemie. Volume 127:Number 45(2015)
• Page Start: 13482
• Page End: 13486
• Publication Date: 2015-09-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201506781
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to &gt;90 °C) with excellent ²H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.</p> </abstract>