Associations of maternal circulating 25‐hydroxyvitamin D3 concentration with pregnancy and birth outcomes. (11th September 2014)

• Record Type: Journal Article
• Authors: Rodriguez, A; García‐Esteban, R; Basterretxea, M; Lertxundi, A; Rodríguez‐Bernal, C; Iñiguez, C; Rodriguez‐Dehli, C; Tardón, A; Espada, M; Sunyer, J; Morales, E
• Is Part Of: BJOG. Volume 122:Number 12(2015:Dec.)
• Page Start: 1695
• Page End: 1704
• Publication Date: 2014-09-11
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.13074
• Languages: English
• ISSNs: 1470-0328

Abstract

<abstract abstract-type="main" id="bjo13074-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bjo13074-sec-0001" sec-type="section"> <title>Objective</title> <p>To investigate the association of maternal circulating 25‐hydroxyvitamin D3 [25(OH)D3] concentration with pregnancy and birth outcomes.</p> </sec> <sec id="bjo13074-sec-0002" sec-type="section"> <title>Design</title> <p>Prospective cohort study.</p> </sec> <sec id="bjo13074-sec-0003" sec-type="section"> <title>Setting</title> <p>Four geographical areas of Spain, 2003–2008.</p> </sec> <sec id="bjo13074-sec-0004" sec-type="section"> <title>Population</title> <p>Of 2382 mother–child pairs participating in the INfancia y Medio Ambiente (INMA) Project.</p> </sec> <sec id="bjo13074-sec-0005" sec-type="section"> <title>Methods</title> <p>Maternal circulating 25(OH)D3 concentration was measured in pregnancy (mean [SD] 13.5 [2.2] weeks of gestation). We tested associations of maternal 25(OH)D3 concentration with pregnancy and birth outcomes.</p> </sec> <sec id="bjo13074-sec-0006" sec-type="section"> <title>Main outcome measures</title> <p>Gestational diabetes mellitus (GDM), preterm delivery, caesarean section, fetal growth restriction (FGR) and small‐for‐gestational age (SGA), anthropometric birth outcomes including weight, length and head circumference (HC).</p> </sec> <sec id="bjo13074-sec-0007" sec-type="section"> <title>Results</title> <p>Overall, 31.8% and 19.7% of women had vitamin D insufficiency [25(OH)D3 20–29.99 ng/ml] and deficiency [25(OH)D3 < 20 ng/ml], respectively. After adjustment, there was no association between maternal 25(OH)D3 concentration and risk of GDM or preterm delivery. Women with sufficient vitamin D [25(OH)D3 ≥ 30 ng/ml] had a decreased risk of caesarean section by obstructed labour compared with women with vitamin D deficiency [relative risk (RR) = 0.60, 95% CI 0.37, 0.97). Offspring of mothers with higher circulating 25(OH)D3 concentration tended to have smaller HC [coefficient (SE) per doubling concentration of 25(OH)D3, −0.10 (0.05), <italic>P </italic>=<italic> </italic>0.038]. No significant associations were found for other birth outcomes.</p> </sec> <sec id="bjo13074-sec-0008" sec-type="section"> <title>Conclusion</title> <p>This study did not find any evidence of an association between vitamin D status in pregnancy and GDM, preterm delivery, FGR, SGA and anthropometric birth outcomes. Results suggest that sufficient circulating vitamin D concentration [25(OH)D3 ≥ 30 ng/ml] in pregnancy may reduce the risk of caesarean section by obstructed labour.</p> </sec> </abstract>