Influence of the vitreomacular interface on the efficacy of intravitreal therapy for uveitis‐associated cystoid macular oedema. (23rd February 2015)

• Record Type: Journal Article
• Authors: Munk, Marion R.; Ram, Radha; Rademaker, Alfred; Liu, Dachao; Setlur, Vikram; Chau, Felix; Schmidt‐Erfurth, Ursula; Goldstein, Debra A.
• Is Part Of: Acta ophthalmologica. Volume 93:Number 7(2015)
• Page Start: e561
• Page End: e567
• Publication Date: 2015-02-23
• Subjects: Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.12699
• Languages: English
• ISSNs: 1755-375X

Abstract

<abstract abstract-type="main" id="aos12699-abs-0001"> <title>Abstract</title> <sec id="aos12699-sec-0001" sec-type="section"> <title>Purpose</title> <p>To evaluate the effect of the vitreomacular interface (VMI) on treatment efficacy of intravitreal therapy in uveitic cystoid macular oedema (CME).</p> </sec> <sec id="aos12699-sec-0002" sec-type="section"> <title>Methods</title> <p>Retrospective analysis of CME resolution, CME recurrence rate and monthly course of central retinal thickness (CRT), retinal volume (RV) and best corrected visual acuity (BCVA) after intravitreal injection with respect to the VMI configuration on spectral‐domain OCT using chi‐squared test and repeated measures <sc>anova</sc> adjusted for confounding covariates epiretinal membrane, administered drug and subretinal fluid.</p> </sec> <sec id="aos12699-sec-0003" sec-type="section"> <title>Results</title> <p>Fifty‐nine eyes of 53 patients (mean age: 47.4 ± 16.9 years) were included. VMI status had no effect on complete CME resolution rate (p = 0.16, corrected p‐value: 0.32), time until resolution (p = 0.09, corrected p‐value: 0.27) or CME relapse rate (p = 0.29, corrected p‐value: 0.29). Change over time did not differ among the VMI configuration groups for BVCA (p = 0.82) and RV (p = 0.18), but CRT decrease was greater and faster in the posterior vitreous detachment (PVD) group compared to the posterior vitreous attachment (PVA) and vitreous macular adhesion (VMA) groups (p = 0.04). Also, the percentage of patients experiencing a ≥ 20% CRT thickness decrease after intravitreal injection was greater in the PVD group (83%) compared to the VMA (64%) and the PVA (16%) group (p = 0.027), however, not after correction for multiple testing (corrected p‐value: 0.11).</p> </sec> <sec id="aos12699-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The VMI configuration seems to be a factor contributing to treatment efficacy in uveitic CME in terms of CRT decrease, although BCVA outcome did not differ according to VMI status.</p> </sec> </abstract>