Different postprandial lipid metabolism and insulin resistance between non-diabetic patients with and without coronary artery disease. Issue 5 (November 2015)

• Record Type: Journal Article
• Authors: Nakamura, Akihiro; Monma, Yuto; Kajitani, Shoko; Kozu, Katsuya; Ikeda, Shohei; Noda, Kazuki; Nakajima, Sota; Endo, Hideaki; Takahashi, Tohru; Nozaki, Eiji
• Is Part Of: Journal of cardiology. Volume 66:Issue 5(2015:Nov.)
• Page Start: 435
• Page End: 444
• Publication Date: 2015-11
• Subjects: Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2015.02.005
• Languages: English
• ISSNs: 0914-5087

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Postprandial hyperlipidemia and hyperinsulinemia have been thought to play an important role in the development of atherosclerosis. Diabetes mellitus (DM) has an impact on lipid metabolism, however, little is known about the relationship between the postprandial lipid and glucose metabolism in normoglycemic patients with coronary artery disease (CAD).</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">To compare the postprandial lipid and glucose metabolism in normoglycemic patients with and without CAD, a total of 36 normoglycemic patients: 19 patients with stable CAD (CAD group, age 60.2 ± 11.3 years) and 17 patients without CAD (Non-CAD group, age 60.4 ± 9.6 years) were loaded with a high-fat and high-glucose test meal, and the changes in serum level of the lipid and glucose parameters were monitored before and 0, 2, 4, and 6 h later.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">In the Non-CAD group, postprandial serum levels of triglycerides (TG) and remnant-like particle cholesterol increased significantly and reached peak levels at the 4th hour and decreased significantly at the 6th hour of observation, whereas those levels in CAD group kept rising during 6 h of observation. Although there was no significant difference in the area under the curves (AUCs) for the postprandial plasma glucose levels between CAD and Non-CAD group, the AUCs for the postprandial plasma insulin and C-peptide levels were significantly higher in the CAD group than in the Non-CAD group. The AUCs for postprandial TG levels showed good correlation with those for postprandial plasma insulin and C-peptide levels (insulin: <italic>r</italic> = 0.455, <italic>p</italic> < 0.005; C-peptide: <italic>r</italic> = 0.462, <italic>p</italic> < 0.05).</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">These findings suggest that postprandial hyperlipidemia and hyperinsulinemia may have a close relationship in CAD patients without DM and might play an important role in the development of atherosclerosis even before the onset of diabetes.</p> </sec> </abstract>