Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells. Issue 8 (December 2015)

• Record Type: Journal Article
• Authors: Kogel, U.; Gonzalez Suarez, I.; Xiang, Y.; Dossin, E.; Guy, P.A.; Mathis, C.; Marescotti, D.; Goedertier, D.; Martin, F.; Peitsch, M.C.; Hoeng, J.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 8(2015)
• Page Start: 2102
• Page End: 2115
• Publication Date: 2015-12
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.08.004
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Systems toxicology analyses were used to compare an MRTP with a reference cigarette.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Lower volatile constituent concentrations in MRTP than in cigarette smoke extract.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Less cell stress and death occurred with MRTP than 3R4F at equal concentrations.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Less Nrf2 signaling occurred with MRTP than 3R4F at equal concentrations.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Less network perturbation occurred with MRTP than 3R4F at equal concentrations.</p> </list-item> </list> </p> </sec> </abstract>