Dissociation of E-cadherin/β-catenin complex by MG132 and bortezomib enhances CDDP induced cell death in oral cancer SCC-25 cells. Issue 8 (December 2015)

• Record Type: Journal Article
• Authors: Lü, Lanhai; Liu, Xiqiang; Wang, Cheng; Hu, Fengchun; Wang, Jianning; Huang, Hongzhang
• Is Part Of: Toxicology in vitro. Volume 29:Issue 8(2015)
• Page Start: 1965
• Page End: 1976
• Publication Date: 2015-12
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.07.008
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">MG132 or bortezomib inhibited cell proliferation and induced cell death in oral cancer SCC-25 cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">MG132 or bortezomib plus CDDP led to synergistic effects on SCC-25 cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">MG132 or bortezomib damaged E-cadherin/β-catenin complex during cell apoptosis.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">The use of MG132 or bortezomib with CDDP could reverse CDDP resistance in oral cancer.</p> </list-item> </list> </p> </sec> </abstract>