PdII‐Catalyzed Intermolecular Amination of Unactivated C(sp3)H Bonds. Issue 44 (11th September 2015)

• Record Type: Journal Article
• Authors: Gou, Quan; Liu, Gang; Liu, Zi‐Ning; Qin, Jun
• Is Part Of: Chemistry. Volume 21:Issue 44(2015)
• Page Start: 15491
• Page End: 15495
• Publication Date: 2015-09-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201502375
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Pd^II‐catalyzed intermolecular amination of unactivated C(sp³)H bonds has been successfully developed for the first time. This method provides a new way to achieve the challenging intermolecular amination of unactivated C(sp³)H bonds, producing a variety of unnatural β²‐amino carboxylic acid analogues. This C(sp³)H amination protocol is demonstrated with a broad substrate scope, good functional‐group tolerance, and chemoselectivity. It is operated without use of phosphine ligand or external oxidant.</p> </abstract>