Oxidized tyrosinase: A possible antigenic stimulus for non-segmental vitiligo autoantibodies. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Al-Shobaili, Hani A.; Rasheed, Zafar
• Is Part Of: Journal of dermatological science. Volume 79:Issue 3(2015:Sep.)
• Page Start: 203
• Page End: 213
• Publication Date: 2015-09
• Subjects: Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2015.06.009
• Languages: English
• ISSNs: 0923-1811

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0075"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">This study demonstrates the role of oxidized tyrosinase in vitiligo autoimmunity.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Modification in tyrosinase by ROS caused alteration in hydrophobic amino acids.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">ROS-induced epitopes on tyrosinase are strongly recognized by non-segmental Vt-IgG.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Anti-ROS-tyrosinase-IgGs in vitiligo patients were increased with disease duration.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Vitiligo patients' sera contain higher levels of carbonyl contents.</p> </list-item> </list> </p> </sec> </abstract>