Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Chen, Tseng-Cheng; Wu, Chen-Tu; Wang, Cheng-Ping; Hsu, Wan-Lun; Yang, Tsung-Lin; Lou, Pei-Jen; Ko, Jenq-Yuh; Chang, Yih-Leong
• Is Part Of: Oral oncology. Volume 51:Issue 11(2015:Nov.)
• Page Start: 1004
• Page End: 1010
• Publication Date: 2015-11
• Subjects: Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2015.08.011
• Languages: English
• ISSNs: 1368-8375

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title id="st005">Highlights</title> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Our classical treatment for advanced OSCC with necrotic changes are not effective.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Association between HIF-1α and PD-L1 is strong in OSCC surrounding necrosis.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Metastatic lymph node with both necrosis and positive PD-L1 had the worst outcomes.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">PD-L1 immune escape may be one of the underlying sources of treatment resistance.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Anti-PD-L1 immunotherapy may be choice for advanced OSCC patients with necrosis.</p> </list-item> </list> </p> </sec> </abstract>