Exclusive moderate-dose radiotherapy in gastric marginal zone B-cell MALT lymphoma: Results of a prospective study with a long term follow-up. Issue 1 (October 2015)

• Record Type: Journal Article
• Authors: Ruskoné-Fourmestraux, Agnès; Matysiak-Budnik, Tamara; Fabiani, Bettina; Cervera, Pascale; Brixi, Hedia; Le Malicot, Karine; Nion-Larmurier, Isabelle; Fléjou, Jean-Fançois; Hennequin, Christophe; Quéro, Laurent; Groupe d'Étude des Lymphomes Digestifs (GELD) & Fédération Francophone de Cancérologie Digestive, f
• Is Part Of: Radiotherapy and oncology. Volume 117:Issue 1(2015:Oct.)
• Page Start: 178
• Page End: 182
• Publication Date: 2015-10
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.08.029
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st005">Abstract</title> <sec> <title id="st010">Background</title> <p id="sp0005">In gastric MALT lymphomas persisting after <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) eradication, a treatment by moderate-dose radiotherapy (RT) has been proposed but its efficacy has not been confirmed in large prospective series with long term endoscopic follow-up.</p> </sec> <sec> <title id="st015">Method</title> <p id="sp0010">Patients with localised gastric MALT lymphoma persisting after <italic>H. pylori</italic> eradication were offered moderate-dose RT (30 Gy, 2 Gy/fraction) and followed with annual endoscopies. All biopsies before and after RT were reviewed by a committee of pathologists.</p> </sec> <sec> <title id="st020">Results</title> <p id="sp0015">From 1995 to 2011, out of the 232 patients followed prospectively, 53 received RT for persistence of lymphoma after <italic>H. pylori</italic> eradication: either macroscopic ulcer (<italic>n</italic> = 31), or microscopic lymphomatous infiltrate (<italic>n</italic> = 22), after a mean follow-up of 12 and 31 months, respectively. All lymphomas were localised (45 stage IE and 8 stage IIE) and 38 (72%) were <italic>H. pylori</italic>-positive. The mean clinical and endoscopic follow-up from diagnosis was 7.6 years (2.2–19.1). No acute or late toxicity occurred. A complete remission was achieved in all patients but one (98%) with no relapse after a median follow-up of 4.9 years (1.3–16.6) after completion of RT. Overall survival and 5-year disease specific survival were 94% and 100%, respectively. One patient died of gastric adenocarcinoma.</p> </sec> <sec> <title id="st025">Conclusion</title> <p id="sp0020">Moderate-dose RT (30 Gy) is effective and safe for localised gastric MALT lymphoma persisting after <italic>H. pylori</italic> eradication.</p> </sec> </abstract>