Tumor stage, tumor site and HPV dependent correlation of perfusion CT parameters and [18F]-FDG uptake in head and neck squamous cell carcinoma. Issue 1 (October 2015)

• Record Type: Journal Article
• Authors: Nesteruk, Marta; Lang, Stephanie; Veit-Haibach, Patrick; Studer, Gabriela; Stieb, Sonja; Glatz, Stefan; Hemmatazad, Hossein; Ikenberg, Kristian; Huber, Gerhard; Pruschy, Martin; Guckenberger, Matthias; Klöck, Stephan; Riesterer, Oliver
• Is Part Of: Radiotherapy and oncology. Volume 117:Issue 1(2015:Oct.)
• Page Start: 125
• Page End: 131
• Publication Date: 2015-10
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.09.026
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st005">Abstract</title> <sec> <title id="st010">Background and purpose</title> <p id="sp0005">This study investigated whether tumor perfusion, FDG uptake and their correlation depend on tumor stage, site and HPV in head and neck cancer.</p> </sec> <sec> <title id="st015">Material and methods</title> <p id="sp0010">41/55 eligible patients with integrated FDG-PET/perfusion CT from 2 prospective studies were assessed. A GTV<sup>CT</sup> and GTV<sup>PET</sup> were created. Perfusion maps were calculated using singular value decomposition method. Blood volume (BV), blood flow (BF), mean transit time (MTT) and standardized uptake value (SUV) in the tumor were compared to the surrounding tissue using Wilcoxon test and Spearman correlation of perfusion and SUV<sub>mean</sub> in the tumor was studied (<italic>p</italic> = 0.05).</p> </sec> <sec> <title id="st020">Results</title> <p id="sp0015">Perfusion parameters were significantly increased in the GTV<sup>CT</sup> of advanced tumors in comparison to the surrounding soft tissue (<italic>p</italic> < 0.01). Oral cavity and oropharyngeal cancer showed a higher BF than laryngeal cancer (<italic>p</italic> < 0.04). No correlation between perfusion and SUV<sub>mean</sub> was found, however SUV<sub>mean</sub> correlated significantly with BF for the HPV-positive tumors (<italic>r</italic> = 0.86, <italic>p</italic> = 0.04) and with BV for the oropharyngeal cancer (<italic>r</italic> = 0.63, <italic>p</italic> = 0.05).</p> </sec> <sec> <title id="st025">Conclusion</title> <p id="sp0020">Tumor stage, site and HPV are associated with different perfusion or combined perfusion/SUV signatures. Further studies are needed to investigate if these signatures co-determine clinical outcome.</p> </sec> </abstract>