Differentiating between benign and malignant adnexal lesions with contrast-enhanced transvaginal ultrasonography. Issue 2 (November 2015)

• Record Type: Journal Article
• Authors: Szymanski, Marek; Socha, Maciej W.; Kowalkowska, Magdalena E.; Zielińska, Izabela B.; Eljaszewicz, Andrzej; Szymanski, Wieslaw
• Is Part Of: International journal of gynaecology and obstetrics. Volume 131:Issue 2(2015:Nov.)
• Page Start: 147
• Page End: 151
• Publication Date: 2015-11
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1016/j.ijgo.2015.04.047
• Languages: English
• ISSNs: 0020-7292

Abstract

<abstract abstract-type="author" id="ab0005"> <title id="st0005">Abstract</title> <sec> <title id="st0010">Objective</title> <p id="sp0005">To analyze the relationship between contrast kinetics in tumorous vessels and lesion histologic type in an attempt to differentiate between malignant and benign disease.</p> </sec> <sec> <title id="st0015">Methods</title> <p id="sp0010">In a single-center prospective study, patients who had been referred for elective surgery because of a diagnosis of unilateral and/or bilateral adnexal masses were enrolled at Dr Jan Biziel University Hospital, Bydgoszcz, Poland, between January 2012 and September 2013. Participants underwent contrast-enhanced ultrasonography examination (CEUS). Contrast kinetics were obtained and compared with the neovascularization of the tumor. Accuracy, and positive and negative predictive values were calculated.</p> </sec> <sec> <title id="st0020">Results</title> <p id="sp0015">Among 160 enrolled patients, 84 underwent CEUS examination and 51 lesions were studied. Baseline and maximum color Doppler intensities were significantly higher in malignant than in benign tumors (<italic>P</italic> < 0.001 for both). Similarly, the absolute and relative increases in color Doppler intensity were significantly higher in malignant tumors (<italic>P</italic> < 0.001). The estimated positive predictive value was 97.1%, the negative predictive value was 100%, and the accuracy was 100%. Peak enhanced intensity of fractional color Doppler Area and area under the time-intensity curve (S-parameter) correlated significantly with the histology of the lesion (<italic>P</italic> < 0.001). Probability curves demonstrated that higher S-parameter values were correlated with a higher risk of malignancy.</p> </sec> <sec> <title id="st0025">Conclusion</title> <p id="sp0020">Transvaginal CEUS is a reliable and reproducible way to differentiate between benign and malignant adnexal lesions.</p> </sec> </abstract>