Family History and Relapse in Pediatric Acute Myeloid Leukemia. Issue 12 (16th July 2015)

• Record Type: Journal Article
• Authors: Mehrvar, Azim; Tashvighi, Maryam; Faranoush, Mohammad; Reinhardt, Dirk; Niktoreh Mofrad, Naghmeh; Hedayati Asl, Amir Abbas; Alebouyeh, Mardawij
• Is Part Of: Pediatric blood & cancer. Volume 62:Issue 12(2015:Dec.)
• Page Start: 2235
• Page End: 2237
• Publication Date: 2015-07-16
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25649
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25649-sec-0001" sec-type="section"> <p>We report the epidemiology and characteristics of acute myeloid leukemia and outcomes of its treatment with the AML‐BFM 83 protocol at the Mahak Pediatric Cancer Treatment and Research Center, Tehran, Iran, from 2007 to 2012. A positive family history of cancer or leukemia was associated with the risk of relapse (family history of cancer in relapse: n = 11; 61%, <italic>P</italic> = 0.136, leukemia: n = 7; 39%; <italic>P</italic> = 0.016). Treatment‐related mortality was 19% and associated with underweight patients (n = 5; 62.5%; <italic>P</italic> = 0.158). Event‐free and overall survivals were 36% (SE = 3.5) and 44% (SE = 3.4), respectively. These data suggest a possible relationship between family history and relapse rate. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>