Effect of Different Z‐Inducers on the Stabilization of Z Portion in BZ‐DNA Sequence: Correlation Between Experimental and Simulation Data. Issue 11 (14th September 2015)

• Record Type: Journal Article
• Authors: Pietropaolo, Adriana; D'urso, Alessandro; Purrello, Roberto; Berova, Nina
• Is Part Of: Chirality. Volume 27:Issue 11(2015)
• Page Start: 773
• Page End: 778
• Publication Date: 2015-09-14
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22502
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>In this study we show the outstanding agreement between simulation and experimental data concerning the efficient stabilization effect by NaCl of Z conformation. We demonstrate by circular dichroism (CD) experiments that Na⁺ not only is able to induce a B to Z form transition in a short (GC)₃ alternated portion of a sequence having 17 basis, but also is the best stabilizer in comparison with other Z inducers used (spermine and NiCl₂). This result was confirmed by free energy calculations. <italic>Chirality 27:773–778, 2015</italic>. © 2015 Wiley Periodicals, Inc.</p> </abstract>