Can pancreatic neuroendocrine tumour biopsy accurately determine pathological characteristics?. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Rebours, Vinciane; Cordova, Jacqueline; Couvelard, Anne; Fabre, Monique; Palazzo, Laurent; Pierre Vullierme, Marie; Hentic, Olivia; Sauvanet, Alain; Aubert, Alain; Bedossa, Pierre; Ruszniewski, Philippe
• Is Part Of: Digestive and liver disease. Volume 47:Issue 11(2015)
• Page Start: 973
• Page End: 977
• Publication Date: 2015-11
• Subjects: Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2015.06.005
• Languages: English
• ISSNs: 1590-8658

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Assessment of the pathological characteristics of pancreatic neuroendocrine tumours is crucial for appropriate management. We compared preoperative pathological data with surgical specimens for accuracy.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">Surgical patients with pancreatic neuroendocrine tumours who underwent preoperative endoscopic ultrasound-guided fine needle aspiration of the primary tumour or biopsy of liver metastasis were retrospectively included. Tumour differentiation and the Ki67 proliferation index on biopsies were compared with pancreatic specimens.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">Fifty-seven patients were included. A preoperative biopsy of the primary tumour or of a liver metastasis was obtained in 48 and 9 patients respectively. Tumour differentiation was high in 98%, and poor in 2% on biopsy and high in 100% of surgical specimens. Ki67 index values were 0 (0–19) and 2 (0–15) on biopsy and surgical specimens (<italic>p</italic> = 0.01). Correlation between preoperative and surgical findings was stronger for liver (<italic>r</italic> = 0.62, <italic>p</italic> = 0.001) than for pancreas (<italic>r</italic> = 0.23, <italic>p</italic> = 0.11). Correlation for pancreas varied according to the tumour pattern: solid (<italic>r</italic> = 0.24, <italic>p</italic> = 0.16), mixed (<italic>r</italic> = 0.91, <italic>p</italic> = 0.0036) or cystic (<italic>r</italic> = 0.04, <italic>p</italic> = 0.89). Tumour grade was different between pancreatic biopsies and surgical specimens, for grade 1 (63% vs 37%) and grade 2 (28% vs 72%), <italic>p</italic> = 0.0007.</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">Tumour grade assessment is accurate in biopsies of liver metastases of pancreatic neuroendocrine tumours, while pancreatic fine-needle aspiration biopsies are less accurate.</p> </sec> </abstract>