Accuracy and inter-observer agreement of the Procore™ 25 gauge needle for endoscopic ultrasound-guided tissue core biopsy. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Attili, Fabia; Petrone, Gianluigi; Abdulkader, Ihab; Correale, Loredana; Inzani, Frediano; Iglesias-Garcia, Julio; Hassan, Cesare; Andrade Zurita, Santiago; Rindi, Guido; Dominguez-Muñoz, J. Enrique; Costamagna, Guido; Larghi, Alberto
• Is Part Of: Digestive and liver disease. Volume 47:Issue 11(2015)
• Page Start: 943
• Page End: 949
• Publication Date: 2015-11
• Subjects: Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2015.07.003
• Languages: English
• ISSNs: 1590-8658

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Scanty data on the performance of the new 25-gauge Procore™ biopsy needle are available.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">Consecutive patients who underwent endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) using the 25G Procore™ were retrospectively retrieved. All samples were independently reviewed by 3 pathologists for the following: histological, cytological or no specimen, neoplasia, diagnostic or non-diagnostic. Diagnostic accuracy and inter-rater concordance among pathologists were calculated.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">94 patients underwent EUS-FNB of 101 sites (69 solid masses, 25 lymph nodes, 5 wall thickening). Forty-one biopsies (40.5%) were classified as histological samples by at least two pathologists, 29 as cytological (28.7%), 31 had no sample (30.7%). Good and almost perfect agreements among pathologists in defining cytological vs. histological samples (<italic>k</italic> 0.82; 95% CI: 0.74–0.90), diagnostic vs. non-diagnostic (<italic>k</italic> 0.95; 95% CI: 0.85–1.00) and neoplastic vs. non-neoplastic (<italic>k</italic> 0.94; 95% CI: 0.83–1.00). According to consensus rating, 61 cases were diagnostic samples (60.4%). Histological samples were more likely to lead to a correct diagnosis (OR, 4.1; 95% <italic>P</italic> = 0.027), while neoplastic lesions were less likely to be correctly classified than benign (OR, 0.11; <italic>P</italic> = 0.04).</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">EUS-FNB with the Procore™ 25G needle provided samples for histological examination in only 40% of the cases, with 31% of inadequate specimens, despite excellent results in term of inter-observer variability.</p> </sec> </abstract>