Validation of the yale‐brown obsessive compulsive scale modified for binge eating. Issue 7 (1st June 2015)

• Record Type: Journal Article
• Authors: Deal, Linda S.; Wirth, R.J.; Gasior, Maria; Herman, Barry K.; McElroy, Susan L.
• Is Part Of: International journal of eating disorders. Volume 48:Issue 7(2015:Nov.)
• Page Start: 994
• Page End: 1004
• Publication Date: 2015-06-01
• Subjects: Appetite disorders -- Periodicals; Ingestion disorders -- Periodicals; Eating disorders -- Periodicals; 616.8526
• DOI: 10.1002/eat.22407
• Languages: English
• ISSNs: 0276-3478

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="eat22407-sec-0001" sec-type="section"> <title>Objective</title> <p>Establish the Yale–Brown obsessive compulsive scale modified for binge eating (YBOCS‐BE) as a fit for purpose measure of treatment benefit in clinical trials of binge eating disorder (BED).</p> </sec> <sec id="eat22407-sec-0002" sec-type="section"> <title>Methods</title> <p>YBOCS‐BE psychometric properties were evaluated with data from a Phase 2 randomized controlled trial of lisdexamfetamine dimesylate in 260 adults with BED. Assessments included: Cohen's effect size estimates of item‐level sensitivity and scale‐level external responsiveness; item‐to‐total correlations; Cronbach's alpha for internal consistency reliability; Spearman correlations against reference measures for construct validity; known‐groups analyses for discriminating ability; <italic>t</italic> tests of within‐group differences between baseline and post baseline visits for internal responsiveness; and multiple anchor‐based approaches to estimate minimum clinically important change (MCIC).</p> </sec> <sec id="eat22407-sec-0003" sec-type="section"> <title>Results</title> <p>No significant distribution anomalies were seen. Items appear sensitive to treatment group differences. Item‐to‐total correlations were positive. Internal consistency is 0.81. Large correlations (>0.50) were seen between YBOCS‐BE score change and the Clinical Global Impression–Improvement (CGI‐I; 0.58) and score changes for the following; number of binge days (0.38), Clinical Global Impression–Severity (CGI‐S; 0.57), the disinhibition (0.57) and hunger (0.52) subscales of the Three‐Factor Eating Questionnaire (TFEQ), and the Barratt Impulsiveness Scale (BIS‐11; 0.58). MCIC estimates range from −4 to −17.</p> </sec> <sec id="eat22407-sec-0004" sec-type="section"> <title>Discussion</title> <p>The YBOCS‐BE was found to be a reliable and valid measure of an important and unique concept in BED‐related clinical studies. Study limitations include using protocol‐defined BED severity level and the exclusion of psychiatric comorbidities. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:994–1004).</p> </sec> </abstract>