Pharmacokinetics of cefquinome in tilapia (Oreochromis niloticus) after a single intramuscular or intraperitoneal administration. Issue 6 (23rd February 2015)

• Record Type: Journal Article
• Authors: Shan, Q.; Zhu, X.; Liu, S.; Bai, Y.; Ma, L.; Yin, Y.; Zheng, G.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 38:Issue 6(2015)
• Page Start: 601
• Page End: 605
• Publication Date: 2015-02-23
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12219
• Languages: English
• ISSNs: 0140-7783

Abstract

<abstract abstract-type="main" id="jvp12219-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The pharmacokinetics of cefquinome was studied in plasma after a single dose (10 mg/kg) of intramuscular (i.m.) or intraperitoneal (i.p.) administration to tilapia (<italic>Oreochromis niloticus</italic>) in freshwater at 30 °C. Ten fish per sampling point were examined after treatment. The data were fitted to two‐compartment open models following both routes of administration. The estimates of total body clearance (CL/F), volume of distribution (Vd/F), and absorption half‐life (T<sub>1/2ka</sub>) were 0.049 and 0.037 L/h/kg, 0.41 and 0.33 L/kg, and 0.028 and 0.035 h following i.m. and i.p. administration, respectively. After i.m. injection, the elimination half‐life (T<sub>1⁄2β</sub>) was calculated to be 5.81 h, the maximum plasma concentration (C<sub>max</sub>) to be 49.40 μg/mL, the time to peak plasma cefquinome concentration (T<sub>max</sub>) to be 0.14 h, and the area under the plasma concentration–time curve (AUC) to be 204.6 μg h/mL. Following i.p. administration, the corresponding estimates were 6.05 h, 44.39 μg/mL, 0.17 h and 267.8 μg h/mL. The minimum inhibitory concentrations of cefquinome, determined for 30 strains of <italic>Streptococcus agalactiae</italic> isolated from diseased tilapia, ranged from 0.015 to 0.12 μg/mL. Results from these studies support that 10 mg cefquinome/kg body weight daily could be expected to control tilapia bacterial pathogens inhibited <italic>in vitro</italic> by a minimal inhibitory concentration value of ≤2 μg/mL.</p> </abstract>