Hyperparathyroidism Associated with Long‐Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults. Issue 10 (29th September 2015)

• Record Type: Journal Article
• Authors: Hinson, Andrew M.; Wilkerson, Bekka M.; Rothman‐Fitts, Ivy; Riggs, Ann T.; Stack, Brendan C.; Bodenner, Donald L.
• Is Part Of: Journal of the American Geriatrics Society. Volume 63:Issue 10(2015:Oct.)
• Page Start: 2070
• Page End: 2073
• Publication Date: 2015-09-29
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13661
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs13661-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs13661-sec-0001" sec-type="section"> <title>Objectives</title> <p>To measure the effect of proton pump inhibitors (PPIs), with and without concurrent bisphosphonates, on parathyroid hormone (PTH), vitamin D, and calcium.</p> </sec> <sec id="jgs13661-sec-0002" sec-type="section"> <title>Design</title> <p>Retrospective chart review of individuals 60 years and older. Subjects with reduced renal function (creatinine >1.3 mg/dL) and low vitamin D (<30 ng/mL) were excluded.</p> </sec> <sec id="jgs13661-sec-0003" sec-type="section"> <title>Setting</title> <p>Academic geriatric outpatient center in southern midwest.</p> </sec> <sec id="jgs13661-sec-0004" sec-type="section"> <title>Participants</title> <p>Individuals aged 60 and older with concurrent calcium, PTH, vitamin D, and creatinine laboratory measurements (<italic>N</italic> = 80) meeting labeled criteria.</p> </sec> <sec id="jgs13661-sec-0005" sec-type="section"> <title>Measurements</title> <p>Serum calcium, PTH, vitamin D, and creatinine.</p> </sec> <sec id="jgs13661-sec-0006" sec-type="section"> <title>Results</title> <p>Chronic PPI exposure was associated with statistically significantly higher PTH (65.5 vs 30.3 pg/mL, <italic> P</italic> < .001; normal range 10–55 pg/mL) and lower calcium (9.1 vs 9.4 mg/dL, <italic> P</italic> = .02; normal range 8.5–10.5 mg/dL) than no PPI exposure. Chronic PPI exposure with concurrent BP therapy was associated with statistically significantly higher PTH (65.2 vs 43.4 pg/mL, <italic> P</italic> = .05) and lower calcium (9.2 vs 9.6 mg/dL, <italic> P</italic> = .04) than BP therapy only.</p> </sec> <sec id="jgs13661-sec-0007" sec-type="section"> <title>Conclusion</title> <p>Based on the present study, chronic PPI exposure in elderly adults is associated with mild hyperparathyroidism regardless of concurrent oral BP administration.</p> </sec> </abstract>