Resistance Training and White Matter Lesion Progression in Older Women: Exploratory Analysis of a 12‐Month Randomized Controlled Trial. Issue 10 (12th October 2015)

• Record Type: Journal Article
• Authors: Bolandzadeh, Niousha; Tam, Roger; Handy, Todd C.; Nagamatsu, Lindsay S.; Hsu, Chun Liang; Davis, Jennifer C.; Dao, Elizabeth; Beattie, B. Lynn; Liu‐Ambrose, Teresa
• Is Part Of: Journal of the American Geriatrics Society. Volume 63:Issue 10(2015:Oct.)
• Page Start: 2052
• Page End: 2060
• Publication Date: 2015-10-12
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13644
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs13644-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs13644-sec-0001" sec-type="section"> <title>Objectives</title> <p>To assess whether resistance training (RT) slows the progression of white matter lesions (WMLs) in older women.</p> </sec> <sec id="jgs13644-sec-0002" sec-type="section"> <title>Design</title> <p>Secondary analysis of a 52‐week randomized controlled trial of RT, the Brain Power Study.</p> </sec> <sec id="jgs13644-sec-0003" sec-type="section"> <title>Setting</title> <p>Community center and research center.</p> </sec> <sec id="jgs13644-sec-0004" sec-type="section"> <title>Participants</title> <p>Of 155 community‐dwelling women aged 65 to 75 enrolled in the Brain Power Study, 54 who had evidence of WMLs on magnetic resonance imaging (MRI) at baseline were included in this secondary analysis.</p> </sec> <sec id="jgs13644-sec-0005" sec-type="section"> <title>Intervention</title> <p>Participants were randomized to once‐weekly RT (1× RT), twice‐weekly RT (2× RT), or twice‐weekly balance and tone (BAT). Assessors were blinded to participant assignments.</p> </sec> <sec id="jgs13644-sec-0006" sec-type="section"> <title>Measurements</title> <p>WML volume was measured using MRI at baseline and trial completion.</p> </sec> <sec id="jgs13644-sec-0007" sec-type="section"> <title>Results</title> <p>At trial completion, the 2× RT group had significantly lower WML volume than the BAT group (<italic>P</italic> = .03). There was no significant difference between the BAT group and the 1× RT group at trial completion (<italic>P</italic> = .77). Among participants in the two RT groups, reduced WML progression over 12 months was significantly associated with maintenance of gait speed (correlation coefficient (<italic>r</italic>) = −0.31, <italic>P</italic> = .049) but not with executive functions (<italic>r</italic> = 0.30; <italic>P</italic> = .06).</p> </sec> <sec id="jgs13644-sec-0008" sec-type="section"> <title>Conclusion</title> <p>Engaging in progressive RT may reduce WML progression.</p> </sec> </abstract>