Association of total serum antioxidant capacity with the Tei index in echocardiography in patients with microvascular angina. Issue 7 (November 2015)

• Record Type: Journal Article
• Authors: Kilic, Alparslan; Yarlioglues, Mikail; Ercan, Ebru Akgul; Duran, Mustafa; Ugurlu, Murat; Oksuz, Fatih; Ozdemir, Sedat; Kurtul, Alparslan; Karadeniz, Muhammed; Murat, Sani Namik; Korkmaz, Sule; Demirtas, Selda
• Is Part Of: Coronary artery disease. Volume 26:Issue 7(2015:Nov.)
• Publication Date: 2015-11
• Subjects: Coronary heart disease -- Periodicals; Coronary Disease -- Indexes; Coronary Disease -- Periodicals; 616.123005
• DOI: 10.1097/MCA.0000000000000293
• Languages: English
• ISSNs: 0954-6928

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives</title> <p>Cardiac syndrome X (CSX) is a condition characterized by exercise-induced chest pain that occurs considering a normal coronary angiogram. We aimed to investigate the total serum antioxidant capacity (TAC) and biventricular global functions using echocardiography in patients with CSX.</p> </sec> <sec> <title>Patients and methods</title> <p>The study population included 55 patients with typical anginal symptoms and a positive exercise stress test, or ischemia in myocardial perfusion scintigraphy and normal coronary arteries detected angiographically, and 49 healthy volunteers with atypical chest pain and a negative stress test. TAC was assessed from blood samples. Transthoracic echocardiography was performed for the entire study population. The Tei index was calculated using the formula IVCT+IVRT/ET.</p> </sec> <sec> <title>Results</title> <p>TAC was found to be significantly lower in the CSX group compared with the control group (0.70±0.37 vs. 1.5±0.30, respectively, <italic>P</italic><0.001). The Tei index was significantly higher in patients with CSX than the control group (0.60±0.18 vs. 0.42±0.12, respectively, <italic>P</italic><0.001).There was a significant and inverse relationship between TAC and the Tei index (<italic>r</italic>=−0.41, <italic>P</italic><0.001). When we divided the study population according to the normal range of TAC into the decreased TAC group (<1.30 mmol/l), the normal TAC group (1.30–1.77 mmol/l), and the increased TAC group (>1.77 mmol/l), it was found that the Tei index was higher in the decreased TAC group compared with the other groups (0.66±0.18 vs. 0.49±0.10 and 0.46±0.13 mmol/l, <italic>P</italic><0.001, respectively).</p> </sec> <sec> <title>Conclusion</title> <p>Our study suggested that TAC was significantly decreased in CSX patients and decreased antioxidant levels were related to impaired Tei index in echocardiography in patients with microvascular angina.</p> </sec> </abstract>