Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Borén, Jan; Watts, Gerald F.; Adiels, Martin; Söderlund, Sanni; Chan, Dick C.; Hakkarainen, Antti; Lundbom, Nina; Matikainen, Niina; Kahri, Juhani; Vergès, Bruno; Barrett, P. Hugh R.; Taskinen, Marja-Riitta
• Is Part Of: Arteriosclerosis, thrombosis, and vascular biology. Volume 35:Issue 10(2015)
• Publication Date: 2015-10
• Subjects: Arteriosclerosis -- Periodicals; Thrombosis -- Periodicals; Blood-vessels -- Pathophysiology -- Periodicals; Electronic journals; 616.13
• DOI: 10.1161/ATVBAHA.115.305614
• Languages: English
• ISSNs: 1079-5642

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives—</title> <p>Patients with obesity and diabetes mellitus have increased risk of cardiovascular disease. A major cause is an atherogenic dyslipidemia related primarily to elevated plasma concentrations of triglyceride-rich lipoproteins. The aim of this study was to clarify determinants of plasma triglyceride concentration. We focused on factors that predict the kinetics of very-low density lipoprotein 1 (VLDL<sub>1</sub>) triglycerides.</p> </sec> <sec> <title>Approach and Results—</title> <p>A multicenter study using dual stable isotopes (deuterated leucine and glycerol) and multicompartmental modeling was performed to elucidate the kinetics of triglycerides and apoB in VLDL<sub>1</sub> in 46 subjects with abdominal obesity and additional cardiometabolic risk factors. Results showed that plasma triglyceride concentrations were dependent on both the secretion rate (<italic>r</italic>=0.44, <italic>P</italic><0.01; <italic>r</italic>=0.45, <italic>P</italic><0.01) and fractional catabolism (<italic>r</italic>=0.49, <italic>P</italic><0.001; <italic>r</italic>=0.55, <italic>P</italic><0.001) of VLDL<sub>1</sub>-triglycerides and VLDL<sub>1</sub>-apoB. Liver fat mass was independently and directly associated with secretion rates of VLDL<sub>1</sub>-triglycerides (<italic>r</italic>=0.56, <italic>P</italic><0.001) and VLDL<sub>1</sub>-apoB (<italic>r</italic>=0.53, <italic>P</italic><0.001). Plasma apoC-III concentration was independently and inversely associated with the fractional catabolisms of VLDL<sub>1</sub>-triglycerides (<italic>r</italic>=0.48, <italic>P</italic><0.001) and VLDL<sub>1</sub>-apoB (<italic>r</italic>=0.51, <italic>P</italic><0.001).</p> </sec> <sec> <title>Conclusions—</title> <p>Plasma triglyceride concentrations in abdominal obesity are determined by the kinetics of VLDL<sub>1</sub> subspecies, catabolism being mainly dependent on apoC-III concentration and secretion on liver fat content. Reduction in liver fat and targeting apoC-III may be an effective approach for correcting triglyceride metabolism atherogenic dyslipidemia in obesity.</p> </sec> </abstract>