A cholesterol-lowering VLP vaccine that targets PCSK9. Issue 43 (26th October 2015)

• Record Type: Journal Article
• Authors: Crossey, Erin; Amar, Marcelo J.A.; Sampson, Maureen; Peabody, Julianne; Schiller, John T.; Chackerian, Bryce; Remaley, Alan T.
• Is Part Of: Vaccine. Volume 33:Issue 43(2015)
• Page Start: 5747
• Page End: 5755
• Publication Date: 2015-10-26
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.09.044
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">PCSK9 is a molecule that controls the metabolism of low-density lipoprotein cholesterol (LDL-C).</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We have generated virus-like particles based vaccines that induce high-titer antibodies against PCSK9.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Vaccination of mice with PCSK9-VLPs resulted in reduced lipid levels.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Macaques vaccinated with PCSK9-VLPs and coadministered statins had significant reduction in LDL-C levels.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Vaccination against PCSK9 may be an alternative to monoclonal antibody-based therapies.</p> </list-item> </list> </p> </sec> </abstract>