The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [18F]-fluoro-deoxy-glucose. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Neveu, Marie-Aline; Bol, Vanesa; Bol, Anne; Bouzin, Caroline; Grégoire, Vincent; Feron, Olivier; Jordan, Benedicte F.; Gallez, Bernard
• Is Part Of: Radiotherapy and oncology. Volume 116:Issue 3(2015:Sep.)
• Page Start: 400
• Page End: 403
• Publication Date: 2015-09
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.04.023
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st005">Abstract</title> <sec> <p id="sp0005">We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of ¹⁸F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in ¹⁸F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.</p> </sec> </abstract>