Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions. Issue 2 (3rd December 2015)

• Record Type: Journal Article
• Authors: Leelakanok, Nattawut; Fischer, Carol L.; Bates, Amber M.; Guthmiller, Janet M.; Johnson, Georgia K.; Salem, Aliasger K.; Brogden, Kim A.; Brogden, Nicole K.
• Is Part Of: Toxicology letters. Volume 239:Issue 2(2015)
• Page Start: 90
• Page End: 96
• Publication Date: 2015-12-03
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.09.006
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0035"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">HBD3 is a very versatile host defense peptide.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">It has antimicrobial activities, regulates innate immune mechanisms, and regulates chemokine and cytokine responses.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">HBD3 also has cytotoxicity against eukaryotic cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">We show that the cytotoxicity of HBD3 for DCs, NHEKs, hTERT keratinocytes, and GE keratinocytes varied with the cell type and the culture conditions.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Thus HBD3 has some cytotoxicity, which needs to be considered in future studies of HBD3-modulated chemokine and cytokine responses.</p> </list-item> </list> </p> </sec> </abstract>